The four genes most reported to be associated with NAFLD include Patatin-like phospholipase domain-containing protein 3 (PNPLA3), Transmembrane 6 superfamily 2 (TM6SF2), Membrane-Bound O-acyltransferase Domain Containing 7 (MBOAT7), and glucokinase regulator (GCKR) [99]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.