A research study was recently published by Cavalcante et al., 2022, who employed a panel of 46 ancestry informative markers (AIM) to study the association between genetic ancestry with PNPLA3 and TM6SF2 polymorphisms in a group of adult Brazilians with biopsy-proven NAFLD [125]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.