Hyperglycemia and early disglycemia caused by obesity-related insulin resistance or impaired insulin secretion, cause several alterations at the cellular level of vascular tissue that may accelerate the atherosclerotic process: (1) glycosylation of proteins and lipids, which may affect their normal function by disrupting molecular conformation and enzymatic activity, reducing degradation capacity, and impairing receptor recognition. The gene discussed is INS; the disease is Insulin resistance.