NFKB1 and multiple sclerosis: In the context of reducing the risk of multiple sclerosis, olive polyphenols reduce neuroinflammation by decreasing oxidative stress through the reduction of ROS and upregulation of antioxidant enzymes, by the downregulation of pro-inflammatory transcription factors such as NF-kB and AP-1, by regulation of the secretion of pro- and anti-inflammatory cytokines, and by the production of pro-aggressive and regulatory T lymphocytes, and pro-inflammatory and anti-inflammatory microglia.