EDN1 and atherosclerosis: There are many key molecules involved in the laminar shear stress and atherosclerosis pathways, such as endothelin 1 (EDN1), vascular cell adhesion molecule 1 (VCAM1), KLF2, intercellular adhesion molecule 1 (ICAM1), and platelet and endothelial cell adhesion molecule 1 (PECAM1).