Recent studies have shown that RES ameliorates ED and prevents cardiovascular disease via multiple mechanisms, which includes inhibition of oxidative stress and inflammatory responses, regulation of lipid metabolism, enhancement of insulin sensitivity, promotion of GLUT4 expression/translocation and ensuing glucose uptake, and activation of the SIRT1/AMPK signaling pathway and serving as a blood flow mimetic drug via activating Krüppel-like factor 2 (KLF2) [10,11,12,13]. The gene discussed is KLF2; the disease is cardiovascular disorder.