TCF7L2 and neoplasm: The Wnt/β-catenin pathway, once β-catenin dimerizes with the transcriptional factor TCF7L2, alters the transcriptome by which it modifies the cytoskeleton, particularly cell–cell adhesion in E-cadherin–β-catenin–α-catenin complexes so that it contributes to cell specification, tumor proliferation, and metastasis [120].