Aspartate intake was associated with an increased risk of cerebrovascular disease (aspartame: 1.17, 1.03–1.33, p = 0.02), but ACE K and sucralose were not associated with an increased risk of cerebrovascular disease (ACE K: 1.01, 0.79–1.29, p = 0.93; sucralose: 0.99, 0.76–1.29, p = 0.93). This evidence concerns the gene TNK2 and cerebrovascular disorder.