In these mice, cholesterol loading increased the blood total cholesterol and triglyceride levels, increased low-density lipoprotein (LDL) cholesterol, and decreased high-density lipoprotein (HDL) cholesterol; increased hepatic SREBP1 expression by ACE K was accompanied by increased Fasn and Acc1 and decreased Acox, suggesting that ACE K consumption with dietary modifications may result in the worsening of lipid abnormalities and the development of atherosclerosis [11]. This evidence concerns the gene TNK2 and atherosclerosis.