Phthalates appear to play an essential role in the development of obesity, interfering at the level of the expression of key transcription factors in the adipogenesis process, such as SREBP-1c, PPAR-γ, C/EBPα, and LXRα, inducing important metabolic alterations [29]. Here, NR1H3 is linked to obesity due to melanocortin 4 receptor deficiency.