Angiogenesis process is initiated by pro-angiogenic signals, inflammation, ischemia, hypoxia, and other variables that act on cytokines, as well as angiogenic factors like vascular endothelial growth factor (VEGF) or fibroblast growth factor (FGF) in tumor cells, urokinase-type plasminogen activator (uPA), and adrenomedullin (ADM) [38]. This evidence concerns the gene PLAU and neoplasm.