At present, the drugs used in the treatment of ischemic stroke include thrombolytic drugs (t-PA, urokinase, etc.), antithrombotic drugs, antiplatelet drugs, fibrinolytic drugs, microcirculation-improving drugs, etc. t-PA (tissue plasminogen activator) was the first drug approved by FDA for the treatment of stroke in 1996, but due to the strict treatment window of ischemic stroke (within 3 h), many patients could not be treated, and there was a high risk of intracranial hemorrhage rate. Here, PLAT is linked to intracranial hemorrhage.