To reveal the expression of IGF2BP2 in clinical patients, we verified the expression of IGF2BP2 in 98 ESCC tissues and showed that the positive rate of IGF2BP2 in ESCC was as high as 96.9%, which revealed that IGF2BP2 may be an ideal target for ESCC imaging. The gene discussed is IGF2BP2; the disease is esophageal squamous cell carcinoma.