IGHE and atopic eczema: In addition, when ferulic acid was assessed in mice with atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB), it promoted potent anti-inflammatory activity, inhibiting Th2 cytokines and IgE and downregulating TNF-α, IL-4, IL-6, and IL-12 expression, effects that alleviated the DNCB-induced atopic dermatitis [81].