MITF and melanoma: In addition, Hibiscus sabdariffa downregulated the gene expression of several biomarkers of skin pigmentation, such as MITF, tyrosinase, TRP-1, and TRP-2 [53], whereas plant extracts containing Litchi sinensis and Tamarindus indica inhibited TRP-2 activity in melanoma cells and downregulated tyrosinase expression, respectively [28].