B16F10 melanoma cells and CCD-986sk fibroblasts were targeting ferulic acid to demonstrate a whitening effect via the inhibition of melanin synthesis, tyrosinase expression, and MITF expression as well as anti-wrinkle activity, inducing procollagen, hyaluronic acid, and TIMP synthesis, parallel to the inhibition of MMP-1 and MMP-9 expressions [83]. This evidence concerns the gene TYR and melanoma.