Initiation of death receptor signaling activates the proapoptotic protein BID, which leads to the release of cytochrome C from mitochondria; the activation of effector caspases that cleave PARP; and the activation of other proteins responsible for cell shrinkage, DNA fragmentation and chromatin condensation, resulting in apoptosis [22,23], underscoring the importance of targeting the apoptotic cascades in certain cancer treatments [24]. This evidence concerns the gene BID and cancer.