They established radioresistant H1299 NSCLC cells by expressing a mutant hypoxia inducible factor-1α (HIF-1α) and found that treatment with UA increased their radiosensitivity (as evidenced by reduced cell survival), and this effect was associated with reduced endogenous GSH and HIF-1α levels [74]. The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.