AKT1 and neoplasm: However, cytotoxicity against cancerous cells is assumed to involve one or more of the underlying mechanisms: (a) a flavonoid found in propolis can repress angiogenesis and induce apoptosis, thereby acting against the tumor, or (b) it inhibits cancer progression by targeting multiple signaling pathways, including phosphoinositide 3-kinases (PI3K)/Akt and mitogen-activated protein kinase (MAPK) signaling molecules [29].