Inhibition of tumor growth, ↓protein expressions of cyclins D1, D2 and E↓ cyclin-dependent kinase (cdk)2, cdk4 and cdk6 expression.Inhibition phosphorylation of MAPK proteins, PI3K, Akt, NF-kB and IKKa, (v) degradation. Here, CDK4 is linked to neoplasm.