Early BC invades adipocytes in white fat tissue in exchange for cytokines and signaling molecules, whereas BC cells induce the lipolysis and adipocyte phenotype as cancer-associated adipocytes (CADC), an abnormal adipocyte with low lipid droplet accompanied by abnormal expression of adipokine secretion, including leptin, lipocalin, IL-6, CCL2, and CCL5 [90,91,92,93,94,95]. Here, LEP is linked to breast cancer.