NFKB1 and renal carcinoma: Jang, et al. [33] reported that Lactucin induces ROS-mediated apoptosis in human renal cancer cell Caki-1 by downregulating Bcl-2 expression and CFLARL stability where Bcl-2 downregulation was at a transcriptional level caused by inactivation of the NF-κB pathway.