TP53 and colorectal carcinoma: Ting et al. found that total ginsenoside (TGCG) induced cell cycle arrest in G0/G1 and G2/M phases through cMyc- and p53-mediated signaling pathways, and induced HT-29 apoptosis in CRC cells by regulating changes in protein levels of CCND1 and CDK4 [37].