TNF and nephritis: Shuklar et al. mentioned that Pueraria lobata extract has the effect of inhibiting nephritis, and its main mechanism may be related to protein kinase C-α (PKC -α) and nuclear factor kappa-B (NF-κB) pathway downregulation, which exerts therapeutic effects by inhibiting the expression of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) [11].