CDK4 and colorectal carcinoma: Moreover, we used network pharmacology to mine and analyze the targets and signaling pathways of Sandwicensin for the treatment of CRC, and the results showed that Sandwicensin exerts its anti-tumor effects mainly through regulating several cell cycle-related proteins (CCND1, CDK4, etc.)and several proliferation-related proteins (MAPK3, MTOR, etc.).