Table S2 lists the pairs of interacting targets with high confidence scores (confidence scores > 0.95 are considered high), such as AKT1 and NOS3, HIF-1α and STAT3, FOS and JUN, MMP2 and TIMP2, and AKT1 and PIK3CA, suggesting that the interaction of these targets may have a key role in the treatment of CRC with Sandwicensin. This evidence concerns the gene PIK3CA and colorectal carcinoma.