Moscatilin was shown to induce apoptosis in human colorectal cancer cells through tubulin depolymerization, DNA damage and c-Jun N-terminal kinase (JNK) activation [134]; apoptosis of human pancreatic cancer cells via reactive oxygen species and the JNK/stress-activated protein kinases (SAPK) pathway [135]; and apoptosis and mitotic catastrophe in human esophageal cancer cells by early promotion of the M phase cell cycle blockade and the regulation of mitotic catastrophe-associated proteins [136]. Here, MAPK8 is linked to familial pancreatic carcinoma.