Alteration to down-stream signaling of p53 including activation of pro-apoptosis protein, reduction of anti-apoptosis and suppression on protein kinase B (Akt) survival pathway were notified in 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (161)-treated lung cancer cells [152]. The gene discussed is AKT1; the disease is lung cancer.