Hypertension is characterized by enhanced expression of adhesion molecules on blood vessels, the heart, and the kidneys; therefore, enhancing extravasation and accumulation of immune cells such as macrophages and T lymphocytes in these organs; these infiltrating cells secrete and stimulate other immune cells to secrete pro-hypertensive cytokines such as interleukin 6 (IL-6), IL-17 and tumor necrosis factor-α (TNF-α) [14,15]. This evidence concerns the gene TNF and hypertensive disorder.