AKT1 and pulmonary arterial hypertension: Quercetin was shown to also inhibit PASMC proliferation by modulating the expression of various functional proteins that are related to the growth and metastasis pathways of PASMCs in a chronic hypoxia model of PAH; this included the inhibition of the TrkA/AKT signaling pathway, which resulted in decreased migration of PASMCs, cell cycle arrest and apoptosis induction [36].