AKT1 and pulmonary arterial hypertension: In addition, in monocrotaline (MCT) induced PAH rat models, quercetin supplementation was found to decrease proliferating cell nuclear antigen expression and wall thickness and area of pulmonary arteries [46]; it inhibited a decrease in KV currents and the overexpression of 5-HT2A and inducible nitric oxide synthase (NOS) induced by MCT in PASMCs while also reducing AKT and S6 phosphorylation [47].