TNF and Arthritis: Considering the wide use of A. angustifolia in Mexico and its medicinal properties, including its reported efficacy in inflammatory and autoimmune disorders, this work aimed to evaluate the anti-inflammatory effects of extracts and fractions from this plant in murine models of xylene and ear edema, as well as its immunomodulatory activity in carrageenan/kaolin (CK)-induced mono-arthritis through the quantification of the relevant cytokines, such as TNF-α, IL-1α, IL-17, and IL-10.