In general, flavonoids interact with several molecular targets involved in melanoma pathogenesis (Figure 1), such as p53, Bcl-2 [9,36], the MAPK pathway, caspase 3 and 9 [37], mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) [38], the phosphatidylinositol 3-kinase (PI3K)/Akt pathway [39,40] and the cyclin-dependent kinase pathway (Cdk) [22,34,41]. This evidence concerns the gene WNK2 and melanoma.