Peroxisome proliferator-activated (PPAR)-alpha (PPARα) is the most abundant isotype in the liver and hepatocyte that regulate genes involved in fatty acid beta-oxidation and homeostasis in the body regulating the expression of genes and metabolic function expressing its receptor into adipose tissue [52] Its deletion may lead to NAFLD promotion [81] otherwise, an increase of PPAR activity can improve HFD-induced dysbiosis and weight gain in mice [82]. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.