SOCS1 and colitis: Interestingly, some studies revealed that SOCS1 deficiency exacerbates intestinal inflammation and that SOCS1-deficient mice, which are hypersensitive to toll-like receptor (TLR) ligands, showing dysregulated cytokine production that perturbs immune cell activation and triggers the development of systemic autoimmunity suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice [53,54].