The serological (ELISA-IgM/IgG) and cellular (DTH) parameters, in addition to clinical and parasitological examinations, revealed a broad clinical-immunological spectrum of infection consisting of seven profiles: three asymptomatic (Indeterminate Asymptomatic Infection [IAI], Resistant Asymptomatic Infection [RAI], and Final Asymptomatic Infection [FAI]); and four symptomatic (Indeterminate Symptomatic Infection [ISI], Resistant Symptomatic Infection [RSI], Final Symptomatic Infection [FSI], and Early Symptomatic Infection [ESI] [44]. The gene discussed is CD40LG; the disease is infection.