We performed such demonstration in the present work by showing the different capacity of immunomodulatory (CRL1505, IBL027 and UCO25A) and non-immunomodulatory (CRL489 and CRL576) L. rhamnosus to regulate respiratory TLR3-mediated immunity and protect against primary RSV and secondary pneumococcal infections. The gene discussed is TLR3; the disease is pneumococcal infection.