At a molecular level, many genes such as fibrosis-related genes (TGFβ1 and ICAM1), matrix remodeling-related genes (ETS1, ITGβ2, and TIMP2), and the kidney injury-related gene KIM1 were involved in the pathogenesis of DN [4,5,6,61]. Here, HAVCR1 is linked to liver dysplastic nodule.