The main findings of the present study were the ameliorative effect of CM and its EXOs against STZ-induced DN as evidenced by restored kidney function (as indicated by the reduction of serum levels of urea, creatinine, and RBP) and redox balance (as revealed by decreasing MDA levels and increasing SOD, CAT, and GPx activities in the kidney), as well as the inhibited expression of TGFβ1, ICAM1, ETS1, ITGβ2, TIMP2, and KIM1 and the improved renal histology. Here, TIMP2 is linked to liver dysplastic nodule.