INS and type 1 diabetes mellitus: Diabetes is classified into two main types: type 1 Diabetes mellitus is characterized by the complete absence of insulin caused by the destruction of beta cells of Islets of Langerhans of the pancreas due to autoimmune defect while type 2 diabetes mellitus is characterized by compensated weakness of beta cells due to receptor defect or the poor quality of insulin due to toxic agents or viral infection [3].