HBEGF and Alzheimer disease: A previous study using inducible pericyte-deficient mice obtained from a pericyte-specific PDGFRβ-Cre mouse line crossed with Cre-inducible diphtheria toxin receptor mice (iDTR mice) demonstrated the functional role of pericytes in CBF regulation, suggesting that pericyte loss may lead to stroke, Alzheimer’s disease (AD), and other neuronal disorders [72].