Discussion can be summarized that exogenous administration of H2S donor in renal failure hypertensive rats protect kidney from renal ischemia-reperfusion injury by increasing antioxidant activities systemically which in turn reduces levels of ICAM-1 and NF-kB concentration globally and more specifically in the kidney resulting in improved renal excretory functions and increased renal cortical blood perfusion as shown in Figure 9A,B. The gene discussed is ICAM1; the disease is kidney failure.