To check this hypothesis, the present study was designed to investigate the effect of chronic administration of H2S on NF-kB and ICAM-1 concentration in non-renal failure (NRF) and acute renal failure (ARF) rats in the IRI model of the kidney in both normotensive WKY and hypertensive rats (L-NAME-induced). This evidence concerns the gene NFKB1 and acute kidney injury.