Discussion can be summarized that exogenous administration of H2S donor in renal failure hypertensive rats protect kidney from renal ischemia-reperfusion injury by increasing antioxidant activities systemically which in turn reduces levels of ICAM-1 and NF-kB concentration globally and more specifically in the kidney resulting in improved renal excretory functions and increased renal cortical blood perfusion as shown in Figure 9A,B. Here, NFKB1 is linked to kidney failure.