Similarly, serum levels of sJAM-C were significantly increased in SSc patients (median 0.63 ng/mL, IQR 0.37–1.86 ng/mL) compared with healthy controls (median 0.00 ng/mL, IQR 0.00–0.46 ng/mL; p < 0.001; Figure 1B), as well as in both SSc cutaneous subsets vs. controls (lcSSc: median 0.60 ng/mL, IQR 0.37–1.68 ng/mL; dcSSc: median 0.66 ng/mL, IQR 0.37–1.91 ng/mL; both p < 0.001; Figure 1B). This evidence concerns the gene JAM3 and systemic sclerosis.