MAP3K2 and glioblastoma: Recently, it has been proposed that circ-PITX1 exerts itself as a competing endogenous RNA by sponging miR-379-5p to elevate the expression of MAP3K2 and rescue the cell proliferation and apoptosis within the glioblastoma; this is regarded as the most common type of primary malignant tumor to occur in the human central nervous systems [45].