For example, recurrent chromosomal aberrations such as t(15;17) [PML-RARa], t(8;21) [AML1-ETO] and inv(16) [CBFB/MYH11] are frequent, but still around 50% of adult AML patients have a cytogenetically normal karyotype (AML-NK) [3,4,5,6]. The gene discussed is CBFB; the disease is acute myeloid leukemia.