NOTCH1 and B-cell chronic lymphocytic leukemia: Although global NEAT1 expression showed no association with IGHV mutational status, cytogenetic abnormalities, NOTCH1 and TP53 mutational status and clinical outcome, NEAT1_2 isoform expression was significantly higher in IGHV mutated CLL, as well as in cases with 13q deletion or without cytogenetic aberrations.