It has been demonstrated that the levels of miR-15a and miR-16-1 are inversely correlated with the expression of BCL2 antiapoptotic protein in CLL cells and that both miRNAs repress BCL2 at post-transcriptional level through direct interaction with the 3′ UTR of BCL2 mRNA [109]. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.