AIF showed the remarkable anti-cancer effects on both androgen-sensitive LNCaP and castration-resistant C4-2 PCa cells by repressing AR/PSA expression and co-targeting FASN- and HMGCR-mediated fatty acid/lipid and cholesterol biosynthesis leading to inhibition of cell growth, colony formation, migration, and invasion, along with activation of caspase-associated apoptosis. Here, HMGCR is linked to posterior cortical atrophy.