The essential oil purified from bergamot (BEO) has been shown to reduce the in vitro tumorigenicity of SH-SY5Y NB cells, linked to p53 phosphorylation, enhance the expression and activation of the pro-apoptotic factor BAX, reduce the expression of the anti-apoptotic factor Bcl-2, and reduce the phosphorylation of p38, which promote apoptotic pathway activation [57,58]. The gene discussed is TP53; the disease is neuroblastoma.