Curcumin also inhibits NB cell migration [8], motility factor autotaxin (Atx) expression in MYCN-amplified and non-amplified NB cells [40], and matrix metalloproteinase-2 (MMP-2) expression and activates the MMP inhibitor TIMP-1 [41], which together characterize curcumin as a potent inhibitor of NB cell migration and invasion. This evidence concerns the gene TIMP1 and neuroblastoma.