CXCR4 and central nervous system cancer: Interestingly, it was also observed that glioma cells implanted into the neonatal rat forebrain migrated along the abluminal surface of blood vessels in a Cxcl12-Cxcr4 signaling-dependent manner [67,68,69], indicating that the infiltration of glioma in the brain was the recapitulation of the developmental process.