Recently, flow cytometry separation of Astrocyte Derived Extracellular Vesicles (ADEVs) with GFAP revealed upregulation in the symptomatic phase of a MS mouse model [39]; this result exemplifies the astrocyte relevance in neuroinflammation—a process happening in AD, PD, MS, amyotrophic lateral sclerosis (ALS) and aging [40]—but it also reveals how ADEVs could be useful for NDD diagnosis when inflammatory involvement occurs. This evidence concerns the gene GFAP and amyotrophic lateral sclerosis.