Although some studies reported the metastasis of urothelial carcinoma being PSMA-avid in PET images [99], Campbell et al. described a case series of three patients with metastatic urothelial carcinoma evaluated using 18F-DCFPyL PET/CT and IHC, showing low uptake in metastatic sites and low levels or nearly absent PSMA expression in tumor neovessels [100]. This evidence concerns the gene FOLH1 and neoplasm.