The same conclusion was reached by Osman et al., who retrospectively evaluated 764 patients with PCa and 49 possible synchronous malignant tumors (not only pulmonary), underlining that isolated PSMA-positive lung lesions in PCa patients should always be interpreted with caution, via a correlation with clinical and biochemical information (e.g., PSA levels), and may often require a histology confirmation or further imaging examinations, such as 18F-FDG PET/CT [70]. Here, KLK3 is linked to posterior cortical atrophy.