Differing from the majority of mesenchymal tumors, which express PSMA exclusively in tumor neovessels, Vaz et al. described a case of gastrointestinal stromal tumors (GIST) with intense uptake of PSMA based on PET imaging and a high expression level of PSMA in the membrane and cytoplasm of cancer cells [89]. This evidence concerns the gene FOLH1 and gastrointestinal stromal tumor.