Variants in IL13, GATA3, HLA class II regulators, Polymorphic Killer cell immunoglobulin-like receptor (KIR) haplotypes of group B have been shown strongly associated with EBV-negative HL cases in young adults [24,25], whereas polymorphisms close to HLA class I loci were mostly associated with EBV-positive HL [26]. This evidence concerns the gene IL13 and Hodgkins lymphoma.