CXCL8 and asthma: EIB is presented in 52.5% of children with asthma [29,30] and it occurs in 8.6–12% of healthy children aged 7–17 years [31], EIA is triggered by cold and dry air during exercise, causing dehydration of the airways mucosa, resulting in increased osmolarity, contraction of bronchial smooth muscle, and an influx of eosinophils and mast cells that release inflammatory mediators (leukotrienes, histamine, IL-8, tryptase, and prostaglandins) [32].