Lauritsen et al. recently found that SGLT2 inhibition with empagliflozin for 4 weeks reduced the GLUT4 gene and protein expression in abdominal adipose tissue, which could indicate a rebalancing of substrate utilization from glucose oxidation and lipid storage to reduce the glycerol formation in patients with T2DM [68]. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.