On further analysis, we demonstrated that while increases in serum albumin concentration are generally associated with decreased rates of adverse surgical events among patients with hypoalbuminemia and normal serum albumin, the effect is more pronounced among patients with serum albumin concentration near the low end of normal range (3.4–4.4 g/dL) and is not consistently observed among patients with serum albumin concentration in the high normal range (>4.4 g/dL). This evidence concerns the gene ALB and Hypoalbuminemia.