HNF1B and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Accordingly, this disease is often referred to as “ADTKD- (abnormal gene name).” HNF1B aside, the five genetic abnormalities often manifest when abnormal protein accumulates within the cell, bringing about endoplasmic reticulum stress which leads to cell dysfunction and tubulointerstitial damage [65].