REN and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: First proposed in the 2015 Kidney Disease: Improving Global Outcomes (KDIGO) consensus report [41], ADTKD is currently believed to be caused by gene mutations UMOD, REN, MUC1, HNF1B, SEC61A, and DNAJB11 [65,66,67].