The VHL gene is a tumor suppressive gene found on chromosome 3p25-26, and the 25–45% of VHL syndrome patients who have this gene mutation can also present with renal cell carcinoma, pancreatic cysts, central nervous system and retinal hemangioblastoma, and pheochromocytoma [115]. This evidence concerns the gene VHL and hereditary pheochromocytoma-paraganglioma.