In particular, Qin et al. demonstrated that a lower expression of miR-34c in exosomes isolated from CCA cell lines is associated with IL-1β, IL-8, and especially IL-6 secretion in CAFs, promoting fibroblast activation, stimulation of Wnt signaling pathways, tumor cell proliferation, migration, and invasiveness of cancer cells. The gene discussed is IL6; the disease is cholangiocarcinoma.