As discussed by Neumeister et al. [133], BMME targeting drug resistance may be caused by the cross-talk of BMME and MM cells via soluble factors (e.g., IL-6, APRIL, growth factors), and via the integrin-mediated cell adhesion and Notch signaling, resulting in the inhibition of apoptosis [134,135,136], on which the major cytotoxic machinery of immune cells relies [137,138,139,140]. Here, IL6 is linked to Miyoshi myopathy.