An eight-gene signature (IL-8, IL-10, IL-17, CCL3, CCL5, VEGFA, EBI3 and NOS2) involved in B lymphocyte inflammation has also been shown to distinguish the different phases of disease progression (MGUS/smoldering/symptomatic-MM) with an 84% accuracy [13]. The gene discussed is EBI3; the disease is Miyoshi myopathy.