The blockade of NF-kB inhibits the adhesion of MM cells to BMSCs, reduces the secretion of VEGF-2 and FGF-2 and angiogenic cytokines (e.g., VEGF, IL-6, IGF-I, Ang-1 and Ang-2), and consequently stops the growth of MM cells and creates new, activated ECs [118]. This evidence concerns the gene IL6 and Miyoshi myopathy.