INS and thanatophoric dysplasia: For another, TD can cause metabolic disorders (for example, it causes electrolyte disturbances, leading to hypokalemia, hyponatremia, and hypomagnesemia, affects fasting glucose, and leads to a deterioration of glucose tolerance, exacerbating hepatic steatosis, with increased liver triglyceride content, leading to visceral fat accumulation and decreased insulin sensitivity) and interfere with the cardiovascular prognosis of diabetes patients [37,38,39,40].