LMNA and familial dilated cardiomyopathy: In familial DCM with early conduction disease, such as Lamins A and C, which are intermediate filament nuclear envelope proteins encoded by the LMNA gene [60], the pretest probability of finding an LMNA mutation is high, and therefore, the early diagnosis of lamin A/C heart disease is important to plan early cardioverter defibrillator implantation.