For example, evidence has shown that the hypermethylation of the v2 transcript of the SEPT9 gene occurs in almost 100% of colorectal cancer tissues [14], elevated levels of SEPT9 v1 and v4 are common in ovarian cancer [31], and SEPT9 v1 is highly expressed and v2 is less expressed in breast cancer [32]. Here, SEPTIN9 is linked to breast cancer.