Thus, considering the presence of some resemblances between SSc and LoS, including the similarity of in the histological pattern of skin [31], we aimed to evaluate the clinical relevance of selected serum levels of IL-1 family cytokines, IL-1α, IL-1β, IL-18, IL-33, IL-37 and IL-38 in a modest-sized single-center cohort of well-characterized and prospectively followed LoS patients and healthy controls, including comparison before and after the initiation of therapy with the use of the standardized disease assessment tools. This evidence concerns the gene IL18 and systemic sclerosis.