IL1A and systemic sclerosis: Thus, considering the presence of some resemblances between SSc and LoS, including the similarity of in the histological pattern of skin [31], we aimed to evaluate the clinical relevance of selected serum levels of IL-1 family cytokines, IL-1α, IL-1β, IL-18, IL-33, IL-37 and IL-38 in a modest-sized single-center cohort of well-characterized and prospectively followed LoS patients and healthy controls, including comparison before and after the initiation of therapy with the use of the standardized disease assessment tools.