Among 139 pediatric patients with ALL, seventy-eight (56.1%) patients had recurrent genetic abnormalities (ETV6-RUNX1 in 34, high hyperdiploidy in 29, TCF3-PBX1 in 7, KMT2A-rearrangement in 7, and hypodiploidy in 1), and nine (6.5%) patients had complex karyotypes. Here, RUNX1 is linked to acute lymphoblastic leukemia.