The A-disintegrin and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) normally cleaves to vWF polymers, and a higher vWF/ADAMTS13 ratio occurs in ICU-admitted and mechanically ventilated COVID-19 patients, hence demonstrating a possible link between COVID-19, inflammation, and thrombosis [65,66,67]. The gene discussed is VWF; the disease is COVID-19.