The analysis of the different humoral and cellular responses in these two groups of subjects was also taken into consideration: for example, in the study by the group of Tarke et al. [72], T CD4+ and CD8+ cells specific for SARS-CoV-2 are compared to lineages B.1.1.7, B.1.351, P.1 and CAL.20C in convalescent COVID-19 subjects and in subjects vaccinated with mRNA-1273 or BNT162b2. The gene discussed is CD4; the disease is COVID-19.